Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex
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منابع مشابه
Modulatory Effects of Memantine on Neuronal Response Properties in Rat Barrel Cortex
Introduction: Memantine as N-Methyl-D-aspartic acid (NMDA) receptor antagonist is used in some neurological disorders. It has been reported that memantine has modulatory effects on the somatosensory information processing in healthy subjects. This study investigated the effect of memantine on electrophysiological properties of barrel cortex neurons in male rats. Methods: Single unit recording ...
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Introduction: Dimethyl sulfoxide (DMSO) is a chemical often used as a solvent for waterinsoluble drugs. In this study, we evaluated the effect of intracerebroventricular (ICV) administration of DMSO on neural response characteristics (in 1200–1500 μm depth) of the rat barrel cortex. Methods: DMSO solution was prepared in 10% v/v concentration and injected into the later...
متن کاملExcitatory neuronal connectivity in the barrel cortex
Neocortical areas are believed to be organized into vertical modules, the cortical columns, and the horizontal layers 1-6. In the somatosensory barrel cortex these columns are defined by the readily discernible barrel structure in layer 4. Information processing in the neocortex occurs along vertical and horizontal axes, thereby linking individual barrel-related columns via axons running throug...
متن کاملPostnatal Changes of Conduction Velocity of the Fibers in and out of the Mouse Barrel Cortex
There are some conflicts about constancy of conduction velocity (CV) in a given tract of nervous system. By recording excitatory postsynaptic currents (EPSC) in layer IV of the somatosensory cortex we tried to clear changes in CV of thalamocortical tract of mice aged 3 to 50 days old. Field potentials and EPSC were recorded in the layer IV by stimulation of ventrobasal nucleus of thalamus (VB) ...
متن کاملNeonatal lead exposure impairs development of rodent barrel field cortex.
Childhood exposure to low-level lead can permanently reduce intelligence, but the neurobiologic mechanism for this effect is unknown. We examined the impact of lead exposure on the development of cortical columns, using the rodent barrel field as a model. In all areas of mammalian neocortex, cortical columns constitute a fundamental structural unit subserving information processing. Barrel fiel...
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ژورنال
عنوان ژورنال: Nature
سال: 2000
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35021059